Cells from infected DNBS-treated IL-22 -/- mice produced, on average, more IL-10 than WT mice, but this did not reach statistical significance (p = 0.2) ( Fig 7C ).
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IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression.
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diminuta and the highly significant increase in IL-25 mRNA in the parasitised gut of IL-22 -/- could result in increased mobilization of immunoregulatory cells and suppression of concomitant disease in the infected mice.