Five biopsy specimens from the proximal part of the tumor reliably determine HER2 protein expression status in gastric cancer.

For the three different regions within the luminal layer, the percentage of HER2-positive tumor cells was higher in the lateral (anal and oral) regions than in the central region, although this did not reach statistical significance [median percentage of HER2-positive cells in the luminal anal region of 58.3 % (range 4.3–92.2 %) vs 65.0 % (range 4.2–99.7 %) for the luminal oral region and 57.2 % (range 0.0–95.0 %) for the luminal central region; p = 0.98].

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