Local delivery of CpG-B and GM-CSF induces concerted activation of effector and regulatory T cells in the human melanoma sentinel lymph node.

Although this difference was limited and did not reach statistical significance, the changes in NK cell frequencies in the peripheral blood correlated significantly ( p < 0.01) with frequencies of NK cells in SLNs of CpG ± GM-administered patients, suggesting a recruitment of NK cells to the SLN upon CpG ± GM administration (Fig. 2 b).

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