In the Osx-P3 PPR-deficient Tomato + cells, mRNA expression of the bone/cementum matrix protein, osteopontin ( Opn ), showed a trend toward upregulation compared to Osx-P3 PPR WT cells, although this result was not statistically significant ( Fig. 7j , Mann–Whitney's U -test).
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Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation.
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