The α-SMA fraction of the small and of the medium-sized arteries surrounding the GFM of AD subjects was significantly lower than that of their NDCTRL counterparts; the α-SMA fraction of arterioles surrounding the GFM showed a trend of being lower in the AD subjects than in the NDCTRL subjects (Fig. 2 a, right).
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Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy.
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