Barely Significant
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CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer's disease.

Alzheimers Res Ther · 2016 · PMC4837517 · PMID 27094739

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0.0510
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showed a trendp = 0.051so close (0.05 < p ≤ 0.1)
Interestingly, CRTC1 mRNA expression showed a trend to be inversely correlated with Prom1 methylation levels (r Spearman = −0.949, p = 0.051) in the control group; meanwhile, no significant correlation was found between methylation and expression among AD patients (r Spearman = −0.287, p = 0.490). mRNA levels of CRTC1 downstream target genes are altered in Alzheimer’s disease hippocampus We also wanted to test whether CRTC1 -dependent genes were also dysregulated in our set of AD hippocampal samples.

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