Considering the significance of pairwise overlap of MCF-7 insertions with each of the five histone marks, none were statistically significant with the exception of H3K27ac, which was highly significant with a p value of 4.96E-69 (p values for all other pairwise overlaps were 1).
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Gamma-Retrovirus Integration Marks Cell Type-Specific Cancer Genes: A Novel Profiling Tool in Cancer Genomics.
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Fig 5C depicts a clear trend with increasing enrichment for cancer driver genes towards the most highly targeted genes in all four cell lines.