A Balanced Tissue Composition Reveals New Metabolic and Gene Expression Markers in Prostate Cancer.

PLoS One · 2016 · PMC4839647 · PMID 27100877

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

borderline significancep = 0.053so close (0.05 < p ≤ 0.1)

No metabolites were specific for the unbalanced dataset, possibly with an exception of taurine with borderline significance (p = 0.053).

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borderline significantp = 0.054so close (0.05 < p ≤ 0.1)

The expression of succinate genes also showed a comparable expression pattern in the validation data, though SUCLA2 and SDHD were only borderline significant (p = 0.054 and p = 0.066 respectively).

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highly significantno p-value reported

Concordantly, we observe a highly significant downregulation of ACO1 , upregulation of fatty acid synthesis genes ACLY , ACACA and FASN , and downregulation of fatty acid oxidation gene ACACB in the unbalanced dataset where PCa are compared to the stroma.

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did not reach statistical significanceno p-value reported

In the complete dataset, where the statistical power is doubled, citrate levels did not reach statistical significance between cancer and normal samples.

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