Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses.

The common pathways in the experimental SR study and the DILGOM sample were: Cholesterol transport, Sterol transport (both P = 0.048), Cholesterol homeostasis and Sterol homeostasis (both with a borderline significance of P = 0.052) ( Table 1 ).

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Large HDL particles showed a trend of increase during SR ( P before correction for multiple testing <0.05, not significant after correction).

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