Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis.

Interestingly, in those lung cancer patients for whom we have clinical information and a long follow-up over different stages ( n =128), the presence of the ADAR1 gene amplification (in 8.5%, 11 of 128, cases) was associated with a shorter relapse-free survival that was very nearly statistically significant (log-rank test: HR=2.29; 95% CI=0.96–5.48; P =0.054) ( Figure 4c ).

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