Effect of Mineralocorticoid Receptor Antagonists on Cardiac Structure and Function in Patients With Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction: A Meta-Analysis and Systematic Review.

In subgroup analyses, MRA use was associated with a modest reduction in DT with a trend toward significance in the HFPEF group (WMD [95% CI]: −14.4 ms [−29.1 to 0.4]; P =0.06), but not in asymptomatic LVDD subgroup (Figure 3 B).

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31 Although the trial did not reach statistical significance for the primary endpoint, there were several interesting findings that point toward efficacy of MRA in HFPEF.

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