TNF/Ang-II synergy is obligate for fibroinflammatory pathology, but not for changes in cardiorenal function.

Although 6‐week data for profibrotic IL‐13 did not reach statistical significance, IL‐13 levels were slightly elevated in both WT and TNFR1‐KO hearts at the 6‐week time point, confirming our previous observations that lymphokine‐related factors were not affected by TNFR1 deficiency (Duerrschmid et al. 2015 ).

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