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Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.

Mol Biol Cell · 2016 · PMC4850040 · PMID 26960794

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Although there was a trend for the LsATF4-KO mice to exhibit lower total cholesterol during ER stress than with WT, it did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.