Direct stimulation of human fibroblasts by nCeO2 in vitro is attenuated with an amorphous silica coating.

Although these results did not reach statistical significance at 24 h post-treatment, these findings highlight the increased fibrogenic potential of the nCeO 2 compared to the amsCeO 2 , since there was roughly 30 % less deposition of the nCeO 2 at that time. nCeO 2 induces proliferation and collagen I expression in fibroblasts As previously mentioned, nCeO 2 is known to accumulate in the lungs in both humans and in animal models, and has been found in the pulmonary interstitium long after exposure has ceased [ 1 , 6 , 10 ].

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