Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity.

Regarding cytokines, chemokines, and growth factors, patients with higher levels of IL-10 and IL-15 as well as lower levels of TGF-β, RANTES, and EFG had higher hazard ratios for mortality, which were marginally significant after adjusting for age (IL-10, HR = 1.013, 95% CI = 1.002–1.024; IL-15, HR = 1.146, 95% CI = 1.022–1.287; TGF-β, HR = 0.876, 95% CI = 0.770–0.998; RANTES, HR = 0.900, 95% CI = 0.780–1.015; EGF, HR = 0.9633, 95% CI = 0.9303–0.9974).

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The level of serum IgG was inversely correlated with viral loads in both plasma and respiratory secretions although these did not reach statistical significance.

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