PMCA2 membrane expression is not particularly frequent in breast cancer and so in a cohort of 96 tumors this association did not reach statistical significance (Fisher’s exact P = 0.077), nevertheless given that the same trend was observed by others in a separate cohort 19 this relationship could illuminate aspects of the biology underlying PMCA2 function and/or behavior of HER2+ breast tumors.
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The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin.
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0.0770
0.0770