Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts.

We observed that succinate dehydrogenase (SDH) activity was significantly higher in mC9ORF72 fibroblasts compared to control cells and a trend toward an increase was also present in mTDP-43 fibroblasts although it did not reach statistical significance (Fig. 2d ).

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