The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets.

J Inflamm (Lond) · 2016 · PMC4858820 · PMID 27158245

Europe PMC DOI

hedged sentence

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

showed a trendp = 0.058so close (0.05 < p ≤ 0.1)

The AMPK activator metformin only showed a trend towards modulation of WIN effects on MMP-3 in OASFs (p = 0.058).

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