Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction.

J Am Heart Assoc · 2016 · PMC4859354 · PMID 26738788

Europe PMC DOI

hedged sentences

0.0490

closest p · 1.0× alpha

0.1000

boldest claim

The sentences

approached but did not reach significanceP= 0.049actually significant

The differences between the CAD and young healthy male group (0.0017±0.0001) approached but did not reach significance ( P= 0.049; critical α was considered to be 0.025 for this relationship), whereas the similar difference between the older healthy (0.0017±0.0002) and CAD groups achieved significance with P= 0.037 because the critical α was 0.05 (see Statistical Analyses ).

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a trend toward significanceP =.065so close (0.05 < p ≤ 0.1)

Association of CACs was higher in the older healthy group than in the CAD group with a trend toward significance ( P =.065; critical α was 0.05 for this relationship).

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borderline significantP ≤0.07so close (0.05 < p ≤ 0.1)

CAC migration, dependent on intrinsic motility rather than chemotaxis, correlated significantly with eNOS protein levels ( r =0.44, P ≤0.01) with a borderline significant correlation with eNOS mRNA ( r =0.27, P ≤0.07).

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approached significanceP >0.1so close (0.05 < p ≤ 0.1)

Migration toward VEGF was significantly higher in the young male group compared with healthy older adults (24.4±2.9 versus 15.00±3.0 per field, P= 0.015), but none of the other pairwise comparisons for VEGF or control migration approached significance ( P >0.1 for all).

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