Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge.

Effect of an HFHS Diet on LKB1 Activity and AMPK Activation In WT mice, cardiac LKB1 activity was reduced 28% after 4 months on the HFHS diet, but the decrease did not reach statistical significance ( P =0.19) (Figure 4 ).

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