14 The study reported a significant trend towards increased efficacy at MTX doses 2.5–20 mg/week when in combination with adalimumab, but similar clinical, radiographic and functional outcomes at MTX doses of 10 and 20 mg/week in combination with 40 mg/week adalimumab.
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Efficacy of etanercept in combination with methotrexate in moderate-to-severe rheumatoid arthritis is not dependent on methotrexate dosage.
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