Initially, alcohol abuse was linked to Chromosome 4 in the area of LPHN3 utilizing two‐point linkage analysis in families with alcohol dependence to identify a nominally significant locus at D4S244 (Reich et al. 1998 ), which is just under 2.5‐Mb downstream of LPHN3 .
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Behavioral and transcriptomic profiling of mice null for Lphn3, a gene implicated in ADHD and addiction.
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