Protective Role of HLA-DRB1*13:02 against Microscopic Polyangiitis and MPO-ANCA-Positive Vasculitides in a Japanese Population: A Case-Control Study.

When the association between DPB1 and GPA/PR3-AAV was examined, DPB1*04 : 01 (the risk allele for GPA in European populations) also showed a trend for association with predisposition to PR3-AAV in the Japanese population (P = 0.057, OR = 1.89, 95%CI: 1.03–3.45) ( Table 4 ).

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Therefore, our results on these subsets suffer from low detection power ( S2 Table ), and significant associations may emerge when the sample size becomes larger, especially for the alleles which showed uncorrected P values < 0.05 but did not achieve significance following Bonferroni correction.

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