Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells.

Consistent with that finding, patients with CD133 or CD13 over-expression had shorter disease-free survival, though this finding with respect to CD133 did not reach statistical significance ( p = 0.129 and p = 0.024, respectively, log-rank test).

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P < 0.01 was considered highly significant statistically and is marked with a double asterisk.

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