The mutation spectrum in genomic late replication domains shapes mammalian GC content.

In summary, following filtering of putative functional elements, the correlation between ToR and GC content remains highly significant (Supplementary Figure S3I), but its structure is altered and can be attributed mainly to links between late replicating regions and low GC content.

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When such analysis is performed without masking functional sequences (Figure 3D – F and Supplementary Figure S8C–I, left), a clear trend separating derived alleles losing or gaining GC is observed.

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