A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.

PLoS Genet · 2016 · PMC4873152 · PMID 27195491

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Basal mitochondrial respiration was significantly decreased and respiration due to ATP turnover showed a trend towards reduction in RCAN1 ox islets ( S3B and S3C Fig ) demonstrating a consistent respiratory defect with RCAN1 overexpression across multiple aspects of mitochondrial function.

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