Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers.

PLoS One · 2016 · PMC4873180 · PMID 27196317

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quite significantno p-value reported

Considering that these metabolisms represent key functions of hepatocytes, downregulation of these pathways suggested a significant level of de-differentiation of hepatocytes under DEN-induced carcinogenesis, which occurred early in the process, and became quite significant later.

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