Barely Significant
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Long-term effects of penicillin resistance and fitness cost on pneumococcal transmission dynamics in a developed setting.

Infect Ecol Epidemiol · 2016 · PMC4875039 · PMID 27206408

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a significant trendno p-value reported
Moreover, when they analysed by country, none of the countries showed a significant trend in the proportions of single penicillin non-susceptibility.

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