Benzolamide improves oxygenation and reduces acute mountain sickness during a high-altitude trek and has fewer side effects than acetazolamide at sea level.

Pharmacol Res Perspect · 2016 · PMC4876137 · PMID 27433337

Europe PMC DOI

hedged sentences

0.0030

closest p · 0.1× alpha

0.2000

boldest claim

The sentences

highly significantP = 0.003actually significant

Considered overall by ANOVA, the reductions in AMS on benzolamide were significant ( P = 0.02, intention‐to‐treat analysis) or highly significant ( P = 0.003, per‐protocol analysis).

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did not reach statistical significanceP = 0.2not close (p > 0.1)

Although the mean arterialized PaO 2 tended to be higher in the benzolamide group (45.7 mmHg) than in the placebo group (43.6 mmHg), the increase while of similar magnitude to the fall in PaCO 2 did not reach statistical significance ( P = 0.2).

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