Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group.

Finally, we found a near-significant effect of antipsychotic drug use on mean caudate volume (β=0.016; P -value=6.71 × 10 −3 ), implying that caudate volume of depressed patients was greater as the percentage of patients taking antipsychotic drugs was higher ( Supplementary Figure S7 ).

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