The CD45.2 + CD4 + Tconvs from the spleen of the cY145F adoptive transfer showed a trend toward decreased IL‐2 mRNA expression in comparison to the Tconvs from the cSLP76 transfer (Fig. 3 B).
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TCR signaling by conventional CD4<sup>+</sup> T cells is required for optimal maintenance of peripheral regulatory T cell numbers.
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