Function and clinical meaningfulness of treatments for mild Alzheimer's disease.

Although later analyses of the same studies showed statistically significant effects on the ADAS-Cog in mild (MMSE ≥22), moderate (MMSE 16 to 22), and severe (MMSE ≤15) AD groups and statistically significant effects on function, as measured by the PDS in the moderate and severe groups, the difference on function in the mild AD group failed to reach statistical significance in these analyses [22] .

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