T cell-derived interleukin-10 is an important regulator of the Th17 response during lethal alphavirus encephalomyelitis.

By 7 d after infection, however, there was a higher frequency as well as a greater number of CD8 + T cells that expressed IL-10eGFP compared to CD4 + T cells, although this did not reach statistical significance ( Fig. 4 A–C).

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