The molecular, temporal and region-specific requirements of the beta isoform of Calcium/Calmodulin-dependent protein kinase type 2 (CAMK2B) in mouse locomotion.

Camk2b T287A/T287A mice showed a trend towards reduced locomotion compared to their wildtype littermates, however this difference was not significant (effect of genotype: F 1,21 = 3.72, p = 0.07; effect of time: F 1,21 = 6.47, p < 0.001; interaction: F 1,21 = 0.71, p = 0.59, repeated measures ANOVA; Fig. 1e ).

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We showed here that loss of autophosphorylation of CAMK2B at the T287 site does not significantly affect rotarod behaviour, although a small trend could be seen.

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