HIV and Hepatitis C-Coinfected Patients Have Lower Low-Density Lipoprotein Cholesterol Despite Higher Proprotein Convertase Subtilisin Kexin 9 (PCSK9): An Apparent "PCSK9-Lipid Paradox".

In contrast to IL‐6, there was no significant difference in baseline levels of hs‐CRP among controls, HIV‐infected individuals, and HIV/HCV‐coinfected individuals (median 1.3 mg/L [IQR 0.65–3.1] versus 1.5 mg/L [IQR 0.8–3.5] versus 1.3 mg/L [IQR 0.6–3.7], respectively, P =0.17); correlations of hs‐CRP with PCSK9 were weak overall in the cohort ( r =−0.03, P =0.42) and did not reach statistical significance in any of the 3 groups.

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Neither ALT nor AST reached statistical significance, while the association between HIV/HCV coinfection and PCSK9 levels remained highly significant in the multivariable models.

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