Dose-Volume Response Relationship for Brain Metastases Treated with Frameless Single-Fraction Linear Accelerator-Based Stereotactic Radiosurgery.

Cureus · 2016 · PMC4889452 · PMID 27284495

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did not reach statistical significanceno p-value reported

This parameter of maximum dose per size was found to correlate with local failure for patients treated for a de novo lesion (HR 0.707 95% CI 0.557 – 0.897) and for patients treated in the salvage setting (HR 0.764 95% CI 0.422 – 1.386) but did not reach statistical significance in the salvage setting likely secondary to only 57 lesions being treated.

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