The hormone response element mimic sequence of GAS5 lncRNA is sufficient to induce apoptosis in breast cancer cells.

In these screening studies, nucleofection of both unmodified RNA and RNA(PT) HREM oligonucleotides stimulated the basal apoptosis of MCF7 cells, whereas the LNA oligonucleotide was less effective and did not reach statistical significance (Figure 7A ).

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Since the action of radiation therapy and many chemotherapeutics depends on the engagement of the apoptotic machinery [ 15 , 16 ], this is likely to be significant from a therapeutic perspective.

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