Remarkably, Trast-NG/DOX + 17AAG treatment led to an actual reduction in tumor volume (shrinkage) compared to the pre-treatment tumor volume, clearly observed at later time points (Figure 5A ), although this difference did not reach statistical significance ( p = 0.293).
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Marked enhancement of lysosomal targeting and efficacy of ErbB2-targeted drug delivery by HSP90 inhibition.
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