The prophylactic treatment of 3-month-old 3 × Tg-AD mice showed a trend toward the generation and maintenance of relatively stable and adequate antibody levels over a 7-month period after the last vaccination.
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A novel recombinant 6Aβ15-THc-C chimeric vaccine (rCV02) mitigates Alzheimer's disease-like pathology, cognitive decline and synaptic loss in aged 3 × Tg-AD mice.
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