showed a trendp = 0.057
Anti-VCP1, anti-VCP2, anti-HCP1, and anti-HCP2 IgG in relation to risk factors for disease development and radiological damage HLA- DRB1 -SE was associated with anti-VCP2 ( p < 0.05), and showed a trend for association with anti-HCP2 antibodies ( p = 0.057) in pre-symptomatic individuals.