Barely Significant
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Antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis.

Arthritis Res Ther · 2016 · PMC4891920 · PMID 27255888

1
hedged sentence
0.0570
closest p · 1.1× alpha
0.0570
boldest claim

The sentences

showed a trendp = 0.057so close (0.05 < p ≤ 0.1)
Anti-VCP1, anti-VCP2, anti-HCP1, and anti-HCP2 IgG in relation to risk factors for disease development and radiological damage HLA- DRB1 -SE was associated with anti-VCP2 ( p < 0.05), and showed a trend for association with anti-HCP2 antibodies ( p = 0.057) in pre-symptomatic individuals.

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