Immune response to the HPV-16/18 AS04-adjuvanted vaccine administered as a 2-dose or 3-dose schedule up to 4 years after vaccination: results from a randomized study.

29 However, a nested substudy found that age of the recipient and the number of doses of quadrivalent vaccine administered impacted the development of B-cell and T-cell memory, respectively, and that HPV-18 specific B-cells following administration of the 2D schedule to girls aged 9–13 y failed to reach statistical significance when compared with pre-vaccination levels. 30 A post-hoc analysis of another trial of the quadrivalent vaccine in adolescent girls aged 11–13 y showed that antibody titers to vaccine components appeared similar 12 mo after administration of 2 doses at M0,12 and 29 mo after administration of 3 doses

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