Even more striking, when correlated with ALSFRS-R score, there was a highly significant relationship between disease score and the N:M ratio: as the ALSFRS-R score dropped (and disease became more severe), the N:M ratio significantly increased ( figure 4B ).
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Increased ratio of circulating neutrophils to monocytes in amyotrophic lateral sclerosis.
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We observed that the percentage and total number of neutrophils both increased as disease progressed, but the relationship did not reach statistical significance, indicating a lack of correlation between the 2 metrics of disease ( figure 2 ).