Interestingly, IL-12 pretreatment resulted in a trend towards increased TCR-induced phosphorylation of LCK and FYN in comparison to cells treated in media alone; however this did not reach statistical significance ( Fig 4C and 4D ).
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Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism.
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