Anti-EBOV GP IgGs Lacking α1-3-Galactose and Neu5Gc Prolong Survival and Decrease Blood Viral Load in EBOV-Infected Guinea Pigs.

There was a low but borderline significance (Mann Whitney test, p = 0.055) of the viral genome load in the anti-EBOV IgG treated guinea pigs compared to the untreated animals, with a 3-log median value decrease obtained on day 3 post-infection (i.e., as assessed in 10 animals, in the serum harvested before the second injection of anti-EBOV IgGs in group 4).

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The treatment of laboratory-acquired infection using convalescent phase serum [ 18 ] and early reports of a survival of 7 out of 8 patients after blood transfusions from convalescent patients [ 19 ] spurred further experimental studies, although this last study did not reach statistical significance, and was limited by a late treatment of the patients following exposure to the virus [ 32 ].

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