A similar benefit was seen in DPP-4 inhibitor trials, although with 70 trials to analyze, the 29% reduction in MACE was highly significant [ 41 ].
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Cardiovascular Outcome Studies in Diabetes: How Do We Make Sense of These New Data?
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This failed to reach statistical significance due to the small numbers of events, short-term nature of the studies and the low-risk nature of the participants [ 40 ].