Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice.

5a, b ) revealed a highly significant depletion of the presynaptic marker synaptophysin (normalised to the neuronal marker Tuj1) in TgCRND8 cultures when compared to WT ( p < 0.0001) (Fig. 5c ) that appears to worsen with the age of the slice ( p = 0.054).

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Interestingly, whilst Aβ 1-40 remains predominant in the slice tissue, the Aβ 1-42 :Aβ 1-40 ratio is significantly higher in slice tissue when compared to the culture medium ( p < 0.0001), with a strong trend for this difference to increase with the age of the slice (p = 0.055) .

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