36 In a similar population and study design, the rates of withdrawal due to adverse effects with fulranumab (OR: 1.77; CI: 0.74–4.22) or fasinumab (OR: 1.53; CI: 0.50–4.73) failed to reach statistical significance. 36 In the meta-analysis 36 of the tanezumab-plus-NSAID combination therapy vs NSAID alone in OA patients, withdrawals due to adverse events reached statistical significance (OR: 1.90; CI: 1.39–2.61).
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