Barely Significant
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Doubling of serum creatinine and the risk of cardiovascular outcomes in patients with chronic kidney disease and type 2 diabetes mellitus: a cohort study.

Clin Epidemiol · 2016 · PMC4910685 · PMID 27354825

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As there were only 3,718 such patients in total, most risk estimates did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.