Paradoxical Autoinflammatory Skin Reaction to Tumor Necrosis Factor Alpha Blockers Manifesting as Amicrobial Pustulosis of the Folds in Patients With Inflammatory Bowel Diseases.

Overproduction of molecules responsible for inhibitory signals aimed at attenuating MMP-mediated inflammation was also demonstrated: TIMP-1 (47.02 ± 83.04 versus 4.45 ± 1.63; P = 0.004) and TIMP-2 (107.45 ± 111.29 versus 48.69 ± 24.40), the latter, however, did not reach statistical significance (Fig. 8 ).

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