The AC/AG Diplotype for the 118A>G and IVS2 + 691G>C Polymorphisms of OPRM1 Gene is Associated with Sleep Quality Among Opioid-Dependent Patients on Methadone Maintenance Therapy.

Pain Ther · 2016 · PMC4912965 · PMID 26792136

Europe PMC DOI

hedged sentences

0.0810

closest p · 1.6× alpha

0.4990

boldest claim

The sentences

did not reach statistical significancep = 0.081so close (0.05 < p ≤ 0.1)

Results Patients with IVS2 + 691 CC genotype had higher PSQI scores [mean (SD) = 5.73 (2.89)] compared to those without the IVS2 + 691 CC genotype (IVS2 + 691 GG/GC genotype) [4.92 (2.31)], but the difference did not reach statistical significance ( p = 0.081).

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did not quite reach statistical significancep = 0.499not close (p > 0.1)

Association of OPRM1 Polymorphisms with PSQI Scores Table 1 shows that patients with homozygous 118 AA genotype had lower PSQI scores compared to those without 118 AA genotype (118 AG/GG genotype) (5.28 vs 5.58), but the difference did not quite reach statistical significance ( p = 0.499).

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